LiquidBiopsy® Testing Services

The Highly Sensitive Blood Test to Analyze and Molecularly Characterize Tumor DNA

Cynvenio’s LiquidBiopsy® assay for solid tumors provides efficient and reliable tumor DNA recovery from whole blood samples. Once recovered, ctcDNA can be returned to the client for in-house analysis or processed at the LiquidBiopsy CLIA lab for analysis of mutational hot spots across 50 oncogenes.

The LiquidBiopsy® test uniquely supports NGS based analysis of both ctDNA and ctcDNA. As such it is the only approach that acknowledges shared and emerging utility of ctcDNA and ctDNA. 

 
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Utility of ctcDNA and ctDNA

CTC and ctcDNA ctDNA
Historical role Prognosis NA
Applications Pathology and IF NA
Nucleic Acids DNA + RNA DNA Only
Disadvantages Enrichment necessary Very high signal:noise
Advantages Accessible sample, good concordance with biopsy, multiple readouts, biologically relevant, tunable Accessible sample, good concordance with biopsy, detected in multiple stages

Supporting Research & Clinical Trial Management

LiquidBiopsy test results can offer early surrogate readout of treatment response, help identify clinically relevant patient sub-populations, and enable adaptive clinical trials, and ultimately, support the development of highly tumor-specific therapies. 

  • Blood samples from subjects can be drawn and the tumor DNA immediately analyzed, or banked for later analysis.

  • Ease of sample collection and the ability to bank samples enables multi-country clinical trials.

  • Resistant or responsive clones within a tumor are accessible even if they occur at a frequency of 1% in the blood. 

  • Analysis supports ctcDNA as well as ctDNA.

  • Rapid "sample-to-sequence" turn-around time.  

Easy Sample Collection & Transport

LiquidBiopsy kits are designed to simplify the collection of tumor cell and cell-free templates for transport to the lab.  The kit includes a custom stabilizer and easy-to-follow instructions for shipping the samples for up to 96 hours at ambient temperature. This 4-day window allows for a streamlined collection process and global transport of samples with no cold-chain requirements.    

 
Kits provide 4-day sample stability and allow unrefrigerated transport.

Kits provide 4-day sample stability and allow unrefrigerated transport.